Doug, a husband and father with brain cancer, drives his wheelchair at a BBQ. Everyone but his son think that it was suicide from the pain but House will stop at nothing to figure out his true ailment.

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Clancy, a 7 year old boy, who believes he is being tortured by aliens comes to the hospital because of rectal bleeding. When House, who thinks he did not solve his last case and it's effecting him physically, finds a medal object in his neck where Clancy claims a chip has been planted and when a cell with a different DNA is found, the team has to give his alien theory more credit. But House's humiliation from his last case and worsening leg pain causes him to back out forcing Cuddy, who lied to House about curing his last patient, rethinks her decision to withhold information.

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House puts a well-known medical researcher through a battery of tests to determine why he collapsed in his lab. When the team is unable to diagnose the problem, the doctor asks the team to help him end his life. House is forced to use his cane again after the ketamine has worn off as he deals with a clinic patient's teenaged daughter who has a crush on him.

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When three previous doctors are not able to diagnose why a severely autistic boy screams loudly for no apparent reason, House takes the case. Although the boy isn't sick, it becomes obvious to the team that House relates to the boy because he can't lie.

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House takes the case of a young woman who has been rushed to the hospital with problems breathing and severe stomach pain after she and her husband were robbed. After her husband collapses, the team believes the couple's illnesses are related. Meanwhile, Michael Tritter, a clinic patient, causes problems for House that could have serious ramifications.

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The team encounters logistical problems while trying to run tests on a 600-pound man due to his extremely large size. Meanwhile, House spends the night in jail after being arrested by Detective Tritter for various charges, including resisting arrest.

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House decides to awaken a comatose patient so he can question the man regarding the family history of his son, who may have a genetic condition and the father is the only living relative. Meanwhile, Wilson confronts House about the stolen prescription pad as Tritter approaches Cameron, Chase, and Foreman in an attempt to divide the team and reveal their loyalties.

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An 18-year-old teenager is brought to the hospital after having a heart attack. House reviews the boy's file and believes he has the diagnosis. He then turns the case into a game by sealing his opinion in an envelope and challenging Cameron, Foreman, and Chase to guess House's diagnosis on their own. Meanwhile, Tritter's actions against Wilson continue to strain the oncologist's relationship with House and destroy his ability to practice medicine.

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House takes the case of a young girl who has been diagnosed with pancreitis. When he takes her divorced parents to court to force them to allow treatment because they can't agree, the judge awards guardianship of the girl to Cuddy. Meanwhile, Tritter continues his strategy to force House to admit to his drug use by offering one of the team members a deal.

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Wilson arranges for House to make a deal with Tritter, but House refuses. Meanwhile, Cuddy cuts House off Vicodin and removes him from the team's case: a 15-year-old little person who entered the hospital with a collapsed lung and anemia.

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House splits his time between treating a firefighter for uncontrollable shivering, giving Tritter a piece of his mind, and handling his trial for forging prescriptions.

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House and his staff must deal with a teenage Gypsy boy suffering from inexplicable respiratory distress. However, House has bigger issues on his mind: Cuddy has given away his handicapped spot.

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While House is forced to work full-time in the clinic and deal with a rape victim who insists on confiding with him, Cameron deals with with a terminal cancer patient trying to take advantage of her state of mind.

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It's Valentine's Day, and Cuddy has a blind date. Meanwhile, House leaves ER duty to take the case of a child patient named Hannah.

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House encounters a brain-damaged musical prodigy with inexplicable abilities while the team faces serious concerns about House's own health.

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The ex-Marine that saved House's life, in a dream he had the day before, is admitted in the hospital with symptoms resembling Gulf War Syndrome. While House is busy dealing with his own health issues, and Chase and Cameron are too busy with each other, the ex-Marine gets worse.

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A famous celebrity photographer suffers from a stroke while being pregnant at her early forties. House and his team have to deal with a great dilemma, save the mother or her unborn child.

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On House and Cuddy's flight from Singapore a passenger gets ill and Cuddy suspects an epidemic. At the hospital, Wilson leads the team as they deal with a middle-aged woman suffering from seizures.

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A 6-year-old girl suffers ailments expected in patients much older. Tensions between Chase and Cameron lead House to intentionally assign them to the same tasks, including investigating the young girl's home.

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The doctors try to find what's wrong with a con artist who collapses after her brain "freezes," but the case becomes personal for Foreman.

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